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The Section on Adolescent Health launched Adolescent Health Update 10 years ago with the goal of providing general pediatricians with practical advice in caring for their adolescent patients. In the first edition, founding editor Mary-Ann B. Shafer, MD, highlighted social and demographic trends affecting adolescents and the rewards of working with adolescents. The publication was an immediate success with pediatricians. T years later, the editorial board strives to achieve that original goal: to identify ways to prepare pediatrien cians for the challenges and rewards of working with adolescents and their families. Adolescent Health Update content is coordinated by an editor, five editorial board members, and five advisory board members. Dr. Shafer and her successor, Donald P. Orr, MD, shared a great depth of clinical knowledge, writing skill, and the ability to synthesize advisory and editorial board input into an article. Joe M. Sanders, Jr, MD, a founding editorial board member and now AAP executive director, has been an unwavering supporter. Dr. Sanders' support has been complemented by the commitment of other AAP leaders, especially within the Section on Adolescent Health, and our wonderful administrative staff, especially Jackie Burke, in the Department of Education, and Michael Hayes, our designer, who "fits us in" between issues of AAP News. The quality of Adolescent Health Update has been sustained by the authors of the articles, experts in their disciplines, yet willing to allow the editorial board to mold the article to the publication's style. Bringing each article to completion, on time and with a professional finish, has been the task of the managing editor, Mariann Stephens. She is a master. Affiliations between Adolescent Health Update and a few individuals come to a close with this issue. We extend our thanks to editorial board member Trina Anglin, MD, PhD. Trina has been an editorial board member for seven years. She is astute, patient, and places a high priority on clinical usefulness. We shall miss her much. We regretfully note the departure of two members of the original AHU Editorial Advisory Board, Donald E. Cook, MD, and Everett Nitzke, MD. We will miss Dr. Cook's terse, on-target comments, and Dr. Nitzke's unerring sense of what "works" with adolescents. We welcome our new editorial board member, Paula Braverman, MD, from Philadelphia, and our new advisory board member, David Y. Rainey, MD, MPH, of Winston-Salem, North Carolina. Dr. Braverman is an associate professor of pediatrics, MCP-Hahnemann School of Medicine, and chief, section of adolescent medicine, St. Christopher's Hospital for Children. Dr. Rainey, who completed fellowship training in adolescent medicine at the University of Colorado, Denver, is an adolescent medicine specialist in private practice. Finally, we acknowledge our partnership with Wyeth-Ayerst Laboratories, whose generous financial support makes all of this possible. No corporation has unlimited resources. Wyeth-Ayerst has chosen to make physician education in adolescent medicine a priority, and we appreciate that. The Academy is developing a research instrument which will survey the Adolescent Health Update readership later this year. Please take the time to respond. As in any long-term partnership, we depend upon our colleagues in general pediatrics for feedback to continue to improve Adolescent Health Update. May the next decade build on the foundation of the first, and may Adolescent Health Update continue on behalf of adolescents' health. Albert C. Hergenroeder, MD Editor and sumycin.

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Marketed products are subject to continued regulatory oversight by the Office of Medical Policy Division of Drug Marketing, Advertising and Communications, and the failure to comply with applicable regulations could result in marketing restrictions, financial penalties and other sanctions. Foreign Regulation Whether or not we obtain FDA approval for a product, we must obtain approval of a product by the comparable regulatory authorities of foreign countries before we can commence clinical trials or marketing of the product in those countries. The approval process varies from country to country, and the time may be longer or shorter than that required for FDA approval. The requirements governing the conduct of clinical trials, product licensing, pricing and reimbursement also vary greatly from country to country. Although governed by the applicable country, clinical trials conducted outside of the United States typically are administered with the three-phase sequential process that is discussed above under "--United States Governmental Regulation." Under European Union regulatory systems, we may submit marketing authorization applications either under a centralized or decentralized procedure. The centralized procedure which is available for medicines produced by biotechnology or which are highly innovative, provides for the grant of a single marketing authorization that is valid for all European Union member states. This authorization is a marketing authorization approval, or MAA. The decentralized procedure provides for mutual recognition of national approval decisions. Under this procedure, the holder of a national marketing authorization may submit an application to the remaining member states. Within 90 days of receiving the applications and assessment report, each member state must decide whether to recognize approval. This procedure is referred to as the mutual recognition procedure, or MRP. In addition, regulatory approval of prices is required in most countries other than the United States. We face the risk that the resulting prices would be insufficient to generate an acceptable return to us or our collaborators. Competition The pharmaceutical industry and the dermatology segment in particular, are highly competitive and include a number of established, large and mid-sized pharmaceutical companies, as well as smaller emerging companies, whose activities are directly focused on our target markets and areas of expertise. Our products compete, and if approved, our product candidates will compete, with a large number of products that include over-the-counter treatments, prescription drugs specifically indicated for a dermatological condition and prescription drugs that are prescribed off-label. In addition, new developments, including the development of other drug technologies and methods of preventing the incidence of disease, occur in the pharmaceutical industry at a rapid pace. These developments may render our product candidates or technologies obsolete or noncompetitive. Each of our marketed products competes, and if approved each of our product candidates will compete, for a share of the existing market with numerous products that have become standard treatments recommended or prescribed by physicians. For example, we believe the primary competition for our marketed products are: For Xolegel, in the treatment of seborrheic dermatitis, Nkzoral from Janssen, Desowen from Galderma S.A., Loprox from Medicis Pharmaceutical Corporation and the generic equivalents of each. For Vusion in the treatment of diaper dermatitis complicated by candidiasis, from ointments and creams containing nystatin, Mycolog II from Bristol-Myers Squibb Company, clotrimazole containing creams from Bayer AG and from generic manufacturers and topical miconazole creams. None of these products are indicated for the treatment of diaper dermatitis complicated by documented candidiasis. 24 and cefixime and Order nizoral online. Other Total n.a. n.a. 300 Animal services dedicated to research into development and control of active molecules in living organisms. Environment, cancer, health. 111 40 151 Mathematical modeling and computer simulations in electrophysiology and biomechanics. 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